Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth
نویسندگان
چکیده
منابع مشابه
Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth.
Insulin receptor substrates, including Irs1 and Irs2, integrate insulin and IGF receptor signals with heterologous pathways to coordinate growth and metabolism. Since Irs2 is thought to be especially important in hepatic nutrient homeostasis, we deleted Irs2 [corrected] from hepatocytes of WT mice (called LKO) or genetically insulin-resistant Irs1-/- mice (called LKO::Irs1-/-). Viable LKO::Irs1...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2006
ISSN: 0021-9738
DOI: 10.1172/jci25735